Reactome | Uncoupled eNOS favours the formation of superoxide

Schema > Reaction > Entries

Uncoupled eNOS favours the formation of superoxide Show undefined attributes

catalystActivity	[CatalystActivity:10378589] superoxide-generating NAD(P)H oxidase activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10378591
displayName	Uncoupled eNOS favours the formation of superoxide
eventOf	[Pathway:R-BTA-203615] eNOS activation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1497810] Uncoupled eNOS favours the formation of superoxide - Homo sapiens
input	[SimpleEntity:R-ALL-29364] NADPH [cytosol] 2 × [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Uncoupled eNOS favours the formation of superoxide NADPH + 2 O2 => H(+) + NADP(+) + 2 superoxide
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] 2 × [SimpleEntity:R-ALL-1222424] O2.- [cytosol]
precedingEvent	[Reaction:R-BTA-1497796] BH2 binding can lead to eNOS uncoupling - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1497810
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-203615] eNOS activation
(inferredTo)	[Reaction:R-HSA-1497810] Uncoupled eNOS favours the formation of superoxide

Cite Us!