Reactome | Activation and oligomerization of BAK protein

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Activation and oligomerization of BAK protein Show undefined attributes

compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10443374
displayName	Activation and oligomerization of BAK protein
eventOf	[Pathway:R-BTA-109606] Intrinsic Pathway for Apoptosis - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2455174] positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-168848] tBID binds to inactive BAK protein - Bos taurus [Reaction:R-BTA-139895] tBID activates BAK protein - Bos taurus [Reaction:R-BTA-114263] Oligomerization of BAK at the mitochondrial membrane - Bos taurus
inferredFrom	[Pathway:R-HSA-111452] Activation and oligomerization of BAK protein - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Activation and oligomerization of BAK protein
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-111452
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-109606] Intrinsic Pathway for Apoptosis
(inferredTo)	[Pathway:R-HSA-111452] Activation and oligomerization of BAK protein

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