Reactome | sacubitrilat [cytosol]

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sacubitrilat [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-GGA-9727599] MME:Zn2+:sacubitrilat [plasma membrane] - Gallus gallus
consumedByEvent	[Reaction:R-CEL-9727607] MME:Zn2+ binds sacubitrilat - Caenorhabditis elegans [Reaction:R-DME-9727607] MME:Zn2+ binds sacubitrilat - Drosophila melanogaster [Reaction:R-GGA-9727607] MME:Zn2+ binds sacubitrilat - Gallus gallus [Reaction:R-XTR-9727607] MME:Zn2+ binds sacubitrilat - Xenopus tropicalis [Reaction:R-SSC-9727607] MME:Zn2+ binds sacubitrilat - Sus scrofa [Reaction:R-BTA-9727607] MME:Zn2+ binds sacubitrilat - Bos taurus [Reaction:R-CFA-9727607] MME:Zn2+ binds sacubitrilat - Canis familiaris [Reaction:R-RNO-9727607] MME:Zn2+ binds sacubitrilat - Rattus norvegicus [Reaction:R-MMU-9727607] MME:Zn2+ binds sacubitrilat - Mus musculus [Reaction:R-HSA-9727607] MME:Zn2+ binds sacubitrilat - Homo sapiens
created	[InstanceEdit:9727622] Jassal, Bijay, 2021-04-19
crossReference	[DatabaseIdentifier:12021040] Mondo:0005009
dbId	9727588
disease	[Disease:9608426] hypertension [Disease:9608422] congestive heart failure
displayName	sacubitrilat [cytosol]
inDisease	true
maxDepth	1
name	sacubitrilat
producedByEvent	[Reaction:R-DDI-9727567] CES1 hydrolyses sacubitril to sacubitrilat - Dictyostelium discoideum [Reaction:R-CEL-9727567] CES1 hydrolyses sacubitril to sacubitrilat - Caenorhabditis elegans [Reaction:R-DME-9727567] CES1 hydrolyses sacubitril to sacubitrilat - Drosophila melanogaster [Reaction:R-GGA-9727567] CES1 hydrolyses sacubitril to sacubitrilat - Gallus gallus [Reaction:R-XTR-9727567] CES1 hydrolyses sacubitril to sacubitrilat - Xenopus tropicalis [Reaction:R-DRE-9727567] CES1 hydrolyses sacubitril to sacubitrilat - Danio rerio [Reaction:R-SSC-9727567] CES1 hydrolyses sacubitril to sacubitrilat - Sus scrofa [Reaction:R-BTA-9727567] CES1 hydrolyses sacubitril to sacubitrilat - Bos taurus [Reaction:R-CFA-9727567] CES1 hydrolyses sacubitril to sacubitrilat - Canis familiaris [Reaction:R-RNO-9727567] CES1 hydrolyses sacubitril to sacubitrilat - Rattus norvegicus [Reaction:R-MMU-9727567] CES1 hydrolyses sacubitril to sacubitrilat - Mus musculus [Reaction:R-HSA-9727567] CES1 hydrolyses sacubitril to sacubitrilat - Homo sapiens
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:7858] sacubitrilat [Guide to Pharmacology:7858]
schemaClass	ChemicalDrug
stId	R-ALL-9727588

Referrals

(input)	[Reaction:R-CEL-9727607] MME:Zn2+ binds sacubitrilat [Reaction:R-DME-9727607] MME:Zn2+ binds sacubitrilat [Reaction:R-GGA-9727607] MME:Zn2+ binds sacubitrilat [Reaction:R-XTR-9727607] MME:Zn2+ binds sacubitrilat [Reaction:R-SSC-9727607] MME:Zn2+ binds sacubitrilat [Reaction:R-BTA-9727607] MME:Zn2+ binds sacubitrilat [Reaction:R-CFA-9727607] MME:Zn2+ binds sacubitrilat [Reaction:R-RNO-9727607] MME:Zn2+ binds sacubitrilat [Reaction:R-MMU-9727607] MME:Zn2+ binds sacubitrilat [Reaction:R-HSA-9727607] MME:Zn2+ binds sacubitrilat
(output)	[Reaction:R-DDI-9727567] CES1 hydrolyses sacubitril to sacubitrilat [Reaction:R-CEL-9727567] CES1 hydrolyses sacubitril to sacubitrilat [Reaction:R-DME-9727567] CES1 hydrolyses sacubitril to sacubitrilat [Reaction:R-GGA-9727567] CES1 hydrolyses sacubitril to sacubitrilat [Reaction:R-XTR-9727567] CES1 hydrolyses sacubitril to sacubitrilat [Reaction:R-DRE-9727567] CES1 hydrolyses sacubitril to sacubitrilat [Reaction:R-SSC-9727567] CES1 hydrolyses sacubitril to sacubitrilat [Reaction:R-BTA-9727567] CES1 hydrolyses sacubitril to sacubitrilat [Reaction:R-CFA-9727567] CES1 hydrolyses sacubitril to sacubitrilat [Reaction:R-RNO-9727567] CES1 hydrolyses sacubitril to sacubitrilat [Reaction:R-MMU-9727567] CES1 hydrolyses sacubitril to sacubitrilat [Reaction:R-HSA-9727567] CES1 hydrolyses sacubitril to sacubitrilat
(hasComponent)	[Complex:R-GGA-9727599] MME:Zn2+:sacubitrilat [plasma membrane] [Complex:R-CFA-9727599] MME:Zn2+:sacubitrilat [plasma membrane] [Complex:R-SSC-9727599] MME:Zn2+:sacubitrilat [plasma membrane] [Complex:R-BTA-9727599] MME:Zn2+:sacubitrilat [plasma membrane] [Complex:R-CEL-9727599] MME:Zn2+:sacubitrilat [plasma membrane] [Complex:R-XTR-9727599] MME:Zn2+:sacubitrilat [plasma membrane] [Complex:R-MMU-9727599] MME:Zn2+:sacubitrilat [plasma membrane] [Complex:R-DME-9727599] MME:Zn2+:sacubitrilat [plasma membrane] [Complex:R-RNO-9727599] MME:Zn2+:sacubitrilat [plasma membrane] [Complex:R-HSA-9727599] MME:Zn2+:sacubitrilat [plasma membrane]

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