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sacubitrilat [cytosol]
Stable Identifier
R-ALL-9727588
Type
ChemicalDrug
Compartment
cytosol
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Physiological factors (Bos taurus)
CES1 hydrolyses sacubitril to sacubitrilat (Bos taurus)
sacubitrilat [cytosol]
MME:Zn2+ binds sacubitrilat (Bos taurus)
sacubitrilat [cytosol]
MME:Zn2+:sacubitrilat [plasma membrane] (Bos taurus)
sacubitrilat [cytosol]
Muscle contraction (Caenorhabditis elegans)
Cardiac conduction (Caenorhabditis elegans)
Physiological factors (Caenorhabditis elegans)
CES1 hydrolyses sacubitril to sacubitrilat (Caenorhabditis elegans)
sacubitrilat [cytosol]
MME:Zn2+ binds sacubitrilat (Caenorhabditis elegans)
sacubitrilat [cytosol]
MME:Zn2+:sacubitrilat [plasma membrane] (Caenorhabditis elegans)
sacubitrilat [cytosol]
Muscle contraction (Canis familiaris)
Cardiac conduction (Canis familiaris)
Physiological factors (Canis familiaris)
CES1 hydrolyses sacubitril to sacubitrilat (Canis familiaris)
sacubitrilat [cytosol]
MME:Zn2+ binds sacubitrilat (Canis familiaris)
sacubitrilat [cytosol]
MME:Zn2+:sacubitrilat [plasma membrane] (Canis familiaris)
sacubitrilat [cytosol]
Muscle contraction (Danio rerio)
Cardiac conduction (Danio rerio)
Physiological factors (Danio rerio)
CES1 hydrolyses sacubitril to sacubitrilat (Danio rerio)
sacubitrilat [cytosol]
Muscle contraction (Dictyostelium discoideum)
Cardiac conduction (Dictyostelium discoideum)
Physiological factors (Dictyostelium discoideum)
CES1 hydrolyses sacubitril to sacubitrilat (Dictyostelium discoideum)
sacubitrilat [cytosol]
Muscle contraction (Drosophila melanogaster)
Cardiac conduction (Drosophila melanogaster)
Physiological factors (Drosophila melanogaster)
CES1 hydrolyses sacubitril to sacubitrilat (Drosophila melanogaster)
sacubitrilat [cytosol]
MME:Zn2+ binds sacubitrilat (Drosophila melanogaster)
sacubitrilat [cytosol]
MME:Zn2+:sacubitrilat [plasma membrane] (Drosophila melanogaster)
sacubitrilat [cytosol]
Muscle contraction (Gallus gallus)
Cardiac conduction (Gallus gallus)
Physiological factors (Gallus gallus)
CES1 hydrolyses sacubitril to sacubitrilat (Gallus gallus)
sacubitrilat [cytosol]
MME:Zn2+ binds sacubitrilat (Gallus gallus)
sacubitrilat [cytosol]
MME:Zn2+:sacubitrilat [plasma membrane] (Gallus gallus)
sacubitrilat [cytosol]
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Physiological factors (Homo sapiens)
CES1 hydrolyses sacubitril to sacubitrilat (Homo sapiens)
sacubitrilat [cytosol]
MME:Zn2+ binds sacubitrilat (Homo sapiens)
sacubitrilat [cytosol]
MME:Zn2+:sacubitrilat [plasma membrane] (Homo sapiens)
sacubitrilat [cytosol]
Muscle contraction (Mus musculus)
Cardiac conduction (Mus musculus)
Physiological factors (Mus musculus)
CES1 hydrolyses sacubitril to sacubitrilat (Mus musculus)
sacubitrilat [cytosol]
MME:Zn2+ binds sacubitrilat (Mus musculus)
sacubitrilat [cytosol]
MME:Zn2+:sacubitrilat [plasma membrane] (Mus musculus)
sacubitrilat [cytosol]
Muscle contraction (Rattus norvegicus)
Cardiac conduction (Rattus norvegicus)
Physiological factors (Rattus norvegicus)
CES1 hydrolyses sacubitril to sacubitrilat (Rattus norvegicus)
sacubitrilat [cytosol]
MME:Zn2+ binds sacubitrilat (Rattus norvegicus)
sacubitrilat [cytosol]
MME:Zn2+:sacubitrilat [plasma membrane] (Rattus norvegicus)
sacubitrilat [cytosol]
Muscle contraction (Sus scrofa)
Cardiac conduction (Sus scrofa)
Physiological factors (Sus scrofa)
CES1 hydrolyses sacubitril to sacubitrilat (Sus scrofa)
sacubitrilat [cytosol]
MME:Zn2+ binds sacubitrilat (Sus scrofa)
sacubitrilat [cytosol]
MME:Zn2+:sacubitrilat [plasma membrane] (Sus scrofa)
sacubitrilat [cytosol]
Muscle contraction (Xenopus tropicalis)
Cardiac conduction (Xenopus tropicalis)
Physiological factors (Xenopus tropicalis)
CES1 hydrolyses sacubitril to sacubitrilat (Xenopus tropicalis)
sacubitrilat [cytosol]
MME:Zn2+ binds sacubitrilat (Xenopus tropicalis)
sacubitrilat [cytosol]
MME:Zn2+:sacubitrilat [plasma membrane] (Xenopus tropicalis)
sacubitrilat [cytosol]
External Reference Information
External Reference
sacubitrilat [Guide to Pharmacology:7858]
Participates
as an input of
MME:Zn2+ binds sacubitrilat (Caenorhabditis elegans)
MME:Zn2+ binds sacubitrilat (Drosophila melanogaster)
MME:Zn2+ binds sacubitrilat (Gallus gallus)
MME:Zn2+ binds sacubitrilat (Xenopus tropicalis)
MME:Zn2+ binds sacubitrilat (Sus scrofa)
MME:Zn2+ binds sacubitrilat (Bos taurus)
MME:Zn2+ binds sacubitrilat (Canis familiaris)
MME:Zn2+ binds sacubitrilat (Rattus norvegicus)
MME:Zn2+ binds sacubitrilat (Mus musculus)
MME:Zn2+ binds sacubitrilat (Homo sapiens)
as an output of
CES1 hydrolyses sacubitril to sacubitrilat (Dictyostelium discoideum)
CES1 hydrolyses sacubitril to sacubitrilat (Caenorhabditis elegans)
CES1 hydrolyses sacubitril to sacubitrilat (Drosophila melanogaster)
CES1 hydrolyses sacubitril to sacubitrilat (Gallus gallus)
CES1 hydrolyses sacubitril to sacubitrilat (Xenopus tropicalis)
CES1 hydrolyses sacubitril to sacubitrilat (Danio rerio)
CES1 hydrolyses sacubitril to sacubitrilat (Sus scrofa)
CES1 hydrolyses sacubitril to sacubitrilat (Bos taurus)
CES1 hydrolyses sacubitril to sacubitrilat (Canis familiaris)
CES1 hydrolyses sacubitril to sacubitrilat (Rattus norvegicus)
CES1 hydrolyses sacubitril to sacubitrilat (Mus musculus)
CES1 hydrolyses sacubitril to sacubitrilat (Homo sapiens)
as a component of
MME:Zn2+:sacubitrilat [plasma membrane] (Rattus norvegicus)
MME:Zn2+:sacubitrilat [plasma membrane] (Sus scrofa)
MME:Zn2+:sacubitrilat [plasma membrane] (Mus musculus)
MME:Zn2+:sacubitrilat [plasma membrane] (Caenorhabditis elegans)
MME:Zn2+:sacubitrilat [plasma membrane] (Drosophila melanogaster)
MME:Zn2+:sacubitrilat [plasma membrane] (Bos taurus)
MME:Zn2+:sacubitrilat [plasma membrane] (Canis familiaris)
MME:Zn2+:sacubitrilat [plasma membrane] (Gallus gallus)
MME:Zn2+:sacubitrilat [plasma membrane] (Xenopus tropicalis)
MME:Zn2+:sacubitrilat [plasma membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
hypertension
DOID:10763
High blood pressure (& [essential hypertension]), HTN, hypertensive disease, hyperpiesia, vascular hypertensive disorder
congestive heart failure
DOID:6000
CHF, Cardiac Failure Congestive, Weak heart, Congestive heart disease
Cross References
Mondo
0005009
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