Reactome | LY3009120 [cytosol]

Schema > ChemicalDrug > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9653106] Rothfels, Karen, 2019-07-09
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575 [DatabaseIdentifier:9717738] ChEBI:167662
dbId	9653105
disease	[Disease:4791250] colorectal cancer
displayName	LY3009120 [cytosol]
inDisease	true
literatureReference	[LiteratureReference:9652925] LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer [LiteratureReference:9652955] Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers
maxDepth	1
memberOf	[DefinedSet:R-ALL-9657579] RAF dimer inhibitors [cytosol]
modified	[InstanceEdit:9717734] Stephan, Ralf, 2021-03-15
name	LY3009120
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:8943] LY3009120 [Guide to Pharmacology:8943]
schemaClass	ChemicalDrug
stId	R-ALL-9653105

(hasMember)	[DefinedSet:R-ALL-9657579] RAF dimer inhibitors [cytosol]
(activeUnit)	[NegativeRegulation:9653114] Negative regulation by 'p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane]'