Reactome | ticagrelor [extracellular region]

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ticagrelor [extracellular region] Show undefined attributes

compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9611251] Jassal, Bijay, 2018-06-18
crossReference	[DatabaseIdentifier:12021046] Mondo:0004995 [DatabaseIdentifier:9627989] ChEBI:68558
dbId	9611252
disease	[Disease:9611312] cerebrovascular disease [Disease:9611005] myocardial infarction [Disease:9611304] cardiovascular system disease
displayName	ticagrelor [extracellular region]
inDisease	true
literatureReference	[LiteratureReference:9611306] Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information [LiteratureReference:9611275] Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation [LiteratureReference:9611263] Effects of P2Y12 receptor antagonists beyond platelet inhibition--comparison of ticagrelor with thienopyridines [LiteratureReference:9611285] Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1 [LiteratureReference:9611297] Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor [LiteratureReference:9611266] Ticagrelor inhibits human platelet aggregation via adenosine in addition to P2Y12 antagonism
maxDepth	1
memberOf	[DefinedSet:R-ALL-9611319] P2RY12 antagonists [extracellular region]
modified	[InstanceEdit:9631716] Wu, G, 2018-12-12
name	ticagrelor
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:1765] ticagrelor [Guide to Pharmacology:1765]
schemaClass	ChemicalDrug
stId	R-ALL-9611252

Referrals

(hasMember)

[DefinedSet:R-ALL-9611319] P2RY12 antagonists [extracellular region]

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