ticagrelor [extracellular region]

Stable Identifier
R-ALL-9611252
Type
ChemicalDrug
Compartment
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
26758983 Effects of P2Y12 receptor antagonists beyond platelet inhibition--comparison of ticagrelor with thienopyridines

Schulz, R, Nylander, S

Br. J. Pharmacol. 2016
24414167 Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1

Ewart, L, VAN Giezen, JJ, Summers, C, Armstrong, D, Sidaway, JE, Nylander, S

J. Cardiovasc. Pharmacol. Ther. 2014
23890048 Ticagrelor inhibits human platelet aggregation via adenosine in addition to P2Y12 antagonism

Nilsson, RG, Asztély, AK, Nylander, S, Löfgren, L, Femia, EA, Berntsson, P, Scavone, M, Nelander, K, Cattaneo, M

J. Thromb. Haemost. 2013
19552634 Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation

Tomlinson, W, Wissing, BM, Nilsson, L, VAN Giezen, JJ, Giordanetto, F, Berntsson, P, Greasley, PJ

J. Thromb. Haemost. 2009
26194851 Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information

Abdelrahman, A, Baqi, Y, Sabbadin, D, Paoletta, S, Zhao, Q, Moro, S, Hinz, S, Straßburger, J, von Kügelgen, I, Katritch, V, Jacobson, KA, Müller, CE, Hoffmann, K, Stevens, RC

J. Comput. Aided Mol. Des. 2015
27694321 Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor

Conibear, A, Mundell, SJ, Mumford, A, Aungraheeta, R, Butler, M, Nylander, S, Kelly, E

Blood 2016
External Reference Information
Participates
Disease
Name Identifier Synonyms
cardiovascular system disease DOID:1287 disease of subdivision of hemolymphoid system
myocardial infarction DOID:5844 heart attack, Myocardial infarct
cerebrovascular disease DOID:6713 Cerebrovascular accident, stroke, cerebrovascular accident, cerebrovascular disorder, CVA
Cross References
ChEBI
Pharos - Ligands
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