Reactome | Positive regulation by 'UDP-Glc [extracellular region]'

Schema > PositiveRegulation > Entries

activeUnit	[EntityWithAccessionedSequence:R-HSA-452514] HAS2 [plasma membrane] - Homo sapiens
activity	[GO_MolecularFunction:81103] hyaluronan synthase activity
created	[InstanceEdit:9941068] Stephan, Ralf, 2025-03-07
dbId	9941160
displayName	Positive regulation by 'UDP-Glc [extracellular region]'
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
regulatedEntity	[Polymerisation:R-HSA-2160851] HAS1,2,3 mediate the polymerization and export of HA - Homo sapiens
regulator	[SimpleEntity:R-ALL-417855] UDP-Glc [extracellular region]
schemaClass	PositiveRegulation

(regulation)	[RegulationReference:9941149] Negative gene expression regulation by 'UDP-Glc [extracellular region]' Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes
(regulatedBy)	[Polymerisation:R-HSA-2160851] HAS1,2,3 mediate the polymerization and export of HA

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