ChAHP is a CHD4-containing complex that plays a role in larg...

created [InstanceEdit:9940461] Rothfels, Karen, 2025-03-05
dbId 9940469
displayName ChAHP is a CHD4-containing complex that plays a role in larg...
modified [InstanceEdit:9945016] Rothfels, Karen, 2025-04-08
schemaClass Summation
text ChAHP is a CHD4-containing complex that plays a role in large scale chromatin organization. In addition to CHD4, the complex also contains CBX1 or CBX3 (also known as HP1 beta and HP1 gamma, respectively) and the transcription factor ADNP (activity-dependent neuroprotector homeobox protein) (Ostapcuk et al, 2018; Kaaij et al, 2019). ChAHP competes for binding at a subset of SINE B2 CTCF-binding sites in the genome to decrease chromatin accessibility (Ostapcuk et al, 2018; Kaaij et al, 2019). ChAHP is recruited to chromatin through sequence-specific binding of ADNP to a GCCCCCTGGAG motif (Ostapcuk et al, 2019). Mutations in ADNP that abrogate the interaction with CBX proteins increase expression of ADNP-target genes, and in humans are associated with autism and neurodevelopmental disorders (Helsmoortel et al, 2014; Ostapcuk et al, 2018; Clemot-Dupont et al, 2025)
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