SWI/SNF complex assembly begins by the binding of a dimer of...

created [InstanceEdit:9932445] Rothfels, Karen, 2024-12-19
dbId 9932439
displayName SWI/SNF complex assembly begins by the binding of a dimer of...
modified [InstanceEdit:9934336] Rothfels, Karen, 2025-01-07
schemaClass Summation
text SWI/SNF complex assembly begins by the binding of a dimer of SMARC subunits (SMARCC1 and SMARCC2, also known as BAF155 and BAF 170, respectively) to SMARCD1, 2 or 3 (also known as BAF60A, BAF60B or BAF60C, respectively) (Mashtalir et al, 2018; Mashtalir et al, 2020). SMARCC has been shown to form dimers in all possible combinations, with SMARCC1 homodimers common in human embryonic stem cells (ESCs) and SMARCC1:SMARCC2 heterodimers occurring in differentiated cell types (Ho et al, 2009; Wang et al, 1996). The SMARCC:SMARCD trimer was identified as the initiating core of SWI/SNF assembly on the basis of density sedimentation and cross-linking analysis of HEK293 nuclear extracts (Mashtalir et al, 2018; Mashtalir et al 2020), in contrast to earlier studies that suggested that complex assembly nucleates around a tetramer of SMARCC1, SMARCC2, SMARCA4 and SMARCB1 (Phelan et al, 1999).
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