After formation of the cBAF core trimer consisting of SMARCC...

created [InstanceEdit:9932445] Rothfels, Karen, 2024-12-19
dbId 9932436
displayName After formation of the cBAF core trimer consisting of SMARCC...
modified [InstanceEdit:9934170] Rothfels, Karen, 2025-01-06
schemaClass Summation
text After formation of the cBAF core trimer consisting of SMARCC1 and SMARCD1, SMARCE1 and SMARCB1 are recruited (Mashtalir et al, 2018). Crosslinking and knockout studies indicate that the SMARCE1 subunit of the cBAF complex is directly recruited through interaction with the SMARCC1 dimer (Mashtalir et al, 2018; Mashtalir et al, 2020). Together, the SMARCC homodimer, SMARCD1, SMARCE1 and SMARCB1 form the cBAF core module that lies adjacent to the nucleosome (Nakayama et al, 2017; Mashtalir et al, 2018; Mashtalir et al, 2020; He et al, 2020). Knockdown of SMARCE1 destabilizes cBAF complex assembly, particularly affecting the recruitment of ARID subunits, while knockdown of SMARCB1 shows minimal effect on cBAF complex assembly but more pronounced effects on pBAF assembly. SMARCE1 and SMARCB1 are dispensable for the assembly of the ncBAF complex (Mashtalir et al, 2018). SMARCB1 has a positive C-terminal alpha-helix that mediates contacts with acidic patches on the nucleosome (He et al, 2020; Mashtalir et al, 2020). Mutations in SMARCB1, common in pediatric rhabdoid tumors, affect the targeting of the SWI/SNF complex to enhancers such that recruitment at "super-enhancers" is maintained at the expense of regular, non-super-enhancer regions (Wang et al, 2017; Nakayama et al, 2017).
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