The phosphorylated CRY:PER:kinase complex, containing CRY1, ...

created [InstanceEdit:9931012] May, Bruce, 2024-12-09
dbId 9931010
displayName The phosphorylated CRY:PER:kinase complex, containing CRY1, ...
modified [InstanceEdit:9935064] May, Bruce, 2025-01-12
schemaClass Summation
text The phosphorylated CRY:PER:kinase complex, containing CRY1, CRY2, PER1, PER2, PER3, and CSNK1D and/or CSNK1E (inferred from mouse homologs), enters the nucleus and binds BMAL1:CLOCK heterodimers bound to E-boxes in circadian regulated target genes (inferred from mouse homologs). Acetylation of BMAL1 enhances the interaction (inferred from mouse homologs). The kinase CSNK1D (and likely CSNK1E), in a complex with CRY and PER proteins, is brought to phosphorylated BMAL1:CLOCK where it further phosphorylates CLOCK, causing dissociation of BMAL1:CLOCK from DNA (inferred from mouse homologs). CRY1, CRY2, and PER2 interact with BMAL1 and PER2 binds CLOCK (inferred from mouse homologs). CRY1 alone is capable of binding BMAL1:CLOCK and repressing transactivation of target genes by BMAL1:CLOCK (inferred from homologs). CRY1 together with PER2 is able to dissociate BMAL1:CLOCK from DNA (inferred from mouse homologs).
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