A dimer of phosphorylated Bmal1:Clock heterodimers binds adj...
| created | [InstanceEdit:9929329] May, Bruce, 2024-11-24 |
| dbId | 9929274 |
| displayName | A dimer of phosphorylated Bmal1:Clock heterodimers binds adj... |
| literatureReference | |
| schemaClass | Summation |
| text | A dimer of phosphorylated Bmal1:Clock heterodimers binds adjacent E-boxes (EE elements, E1E2 elements) in the Per3 promoter (Nakahata et al. 2008, Hatanaka et al. 2010, Rey et al. 2011, Koike et al. 2012 ). Phosphorylated Bmal1:Clock also binds one additional site. The phosphorylated Bmal1:Clock heterodimer recruits the histone acetyltransferase Crebbp (CBP) (Koike et al. 2012) and the histone methyltransferase Kmt2a (Mll1) (inferred from the Per2 promoter in Katada and Sassone-Corsi 2010), and activates transcription. |
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