It is unknown how (S)-4-hydroxymandelate (4-HMA) gets proces...

created [InstanceEdit:9856850] Stephan, Ralf, 2023-12-24
dbId 9856859
displayName It is unknown how (S)-4-hydroxymandelate (4-HMA) gets proces...
modified [InstanceEdit:9857113] Stephan, Ralf, 2024-01-01
schemaClass Summation
text It is unknown how (S)-4-hydroxymandelate (4-HMA) gets processed to 4-hydroxybenzaldehyde (4-HBz). In yeast, the dehydrogenases DLD1 and DLD2 were shown to be necessary for these step(s) (Valera et al., 2020; reviewed in Fernández-del-Río & Clarke, 2021). In humans, the closest homologs of DLD1/2 are mitochondrial LDHD and D2HGDH whose known functions are in D-malate and D-lactate metabolism (Yang et al., 2021; Jin et al., 2023). Hypothetically, they could dehydrogenate 4-hydroxymandelate to 4-hydroxybenzoylformate (4-HBF, 4-hydroxyphenylglyoxylate), and in a second step 4-HBF would be decarboxylated by an unknown enzyme to 4-HBz. Alternatively, 4-HMA could be directly decarboxylated in one step to 4-HBz (Husain et al., 2020; reviewed in Staiano et al., 2023).
Cite Us!