Expression of Gata3 in the developing nephric duct is activa...

created [InstanceEdit:9831436] May, Bruce, 2023-03-20
dbId 9831433
displayName Expression of Gata3 in the developing nephric duct is activa...
modified [InstanceEdit:9832755] May, Bruce, 2023-04-05
schemaClass Summation
text Expression of Gata3 in the developing nephric duct is activated by Lhx1 and Pax2 (Grote et al. 2006, Boualia et al. 2013). Gata3 in turn activates expression of Lhx1 so that Pax2, Lhx1, and Gata3 form the basic regulatory module controlling the renal primordium transcription program (Boualia et al. 2013). Beta-catenin (Ctnnb1) from Wnt signaling also acts upstream of Gata3 to activate expression (Grote et al. 2008). Gata3 then activates expression of a number of downstream genes, including Id4 and Ret, the receptor tyrosine kinase that interacts with Gdnf to induce formation of the ureteric bud (Chia et al. 2011).
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