Reactome | WFDC2 (also called HE4) is strongly expressed in the develop...

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created	[InstanceEdit:9831436] May, Bruce, 2023-03-20
dbId	9831373
displayName	WFDC2 (also called HE4) is strongly expressed in the develop...
literatureReference	[LiteratureReference:9831430] The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma [LiteratureReference:9774516] A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis [LiteratureReference:9832737] WFDC2 suppresses prostate cancer metastasis by modulating EGFR signaling inactivation
modified	[InstanceEdit:9832755] May, Bruce, 2023-04-05
schemaClass	Summation
text	WFDC2 (also called HE4) is strongly expressed in the developing nephric duct (inferred from the mouse homolog in Boualia et al. 2013, inferred from the chicken homolog in Hellstrom et al. 2003). PAX2 activates expression of WFDC2 in nephric duct (inferred from mouse homologs in Boualia et al. 2013). Expression of Wfdc2 is completely lost in mouse embryos homozygous null for Pax2 and heterozygous null for Pax8 (Boualia et al. 2013). WFDC2 is able to regulate EGFR signaling, can downregulate expression of SNAI1 (Snail), CDH2 (N-Cadherin), and Vimentin, and can upregulate expression of CDH1 (E-Cadherin) (Xiong et al. 2020).

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