Reactome | The role of chicken lipopolysaccharide-binding protein (LBP)...

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created	[InstanceEdit:975751] Shamovsky, V, 2010-10-04
dbId	975752
displayName	The role of chicken lipopolysaccharide-binding protein (LBP)...
literatureReference	[LiteratureReference:433799] Lipopolysaccharide binding protein/CD14/ TLR4-dependent recognition of salmonella LPS induces the functional activation of chicken heterophils and up-regulation of pro-inflammatory cytokine and chemokine gene expression in these cells [LiteratureReference:433945] Unique properties of the chicken TLR4/MD-2 complex: selective lipopolysaccharide activation of the MyD88-dependent pathway
modified	[InstanceEdit:977264] D'Eustachio, P, 2010-10-15
schemaClass	Summation
text	The role of chicken lipopolysaccharide-binding protein (LBP) remains unclear. Inspection of the chicken genome showed no ortholog of human LBP (Keestra et al 2008), and LPS induced the functional activation of heterophils without the presence of LBP. Nevertheless, in the reaction shown here we annotated hypothetical chicken LPB using the data and suggestions reported by Kogut et al. (2005), that LBP and CD14/TLR4 induction is directly involved in LPS-mediated functional activation of chicken heterophils.

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