Reactome | Negative regulation by '6:NPC [nuclear envelope]'

Schema > NegativeRegulation > Entries

activeUnit	[EntityWithAccessionedSequence:R-COV-9708916] 6 [cytosol] - Severe acute respiratory syndrome coronavirus 2
created	[InstanceEdit:9757501] Shamovsky, Veronica, 2021-11-01
dbId	9757502
displayName	Negative regulation by '6:NPC [nuclear envelope]'
regulatedEntity	[Reaction:R-HSA-9768142] Dimerized phospho-IRF3, IRF7 is transported to the nucleus - Homo sapiens
regulator	[Complex:R-HSA-9708891] 6:NPC [nuclear envelope]
schemaClass	NegativeRegulation

(regulation)	[RegulationReference:9765931] Negative regulation by '6:NPC [nuclear envelope]' SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling
(regulatedBy)	[Reaction:R-HSA-9768142] Dimerized phospho-IRF3, IRF7 is transported to the nucleus

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