SARS-CoV-1 viroporin 3a is a membrane protein that transloca...

created [InstanceEdit:9731037] Stephan, Ralf, 2021-05-12
dbId 9731071
displayName SARS-CoV-1 viroporin 3a is a membrane protein that transloca...
modified [InstanceEdit:9737724] Shamovsky, Veronica, 2021-07-21
schemaClass Summation
text SARS-CoV-1 viroporin 3a is a membrane protein that translocates to the plasma membrane and, via shedding, to other cells. It forms a homotetrameric inward-rectifying potassium ion channel. While located in the ERGIC or Golgi apparatus it binds to the regulator and scaffolding protein caveolin-1 (CAV1). Through its interaction with CAV1, the 3a protein may regulate virus uptake, as well as the trafficking of structural proteins (Padhan et al. 2007).
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