Coronaviruses are a group of enveloped viruses with single?s...

created [InstanceEdit:9705656] Shamovsky, Veronica, 2020-10-28
dbId 9705659
displayName Coronaviruses are a group of enveloped viruses with single?s...
literatureReference
modified [InstanceEdit:9759409] Shamovsky, Veronica, 2021-12-03
schemaClass Summation
text Coronaviruses are a group of enveloped viruses with single?stranded, positive?sense RNA genomes. Each of the steps of viral replication - attachment and entry, translation of viral replicase, genome transcription and replication, translation of structural proteins, and virion assembly and release - involves host factors. These interactions can cause alterations in cellular structure and physiology, and activate host stress responses, autophagy, cell death, and processes of innate immunity (Fung TS & Liu DX 2019). This Reactome module describes molecular mechanisms by which severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) modulates innate and adaptive immune responses, autophagy, host translation, intracellular signaling and regulatory pathways, and PDZ-mediated cell-cell junctions, mostly annotated from studies of cells infected with SARS-CoV-2.
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