Reactome | Negative regulation by '(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol]'

Schema > NegativeRegulation > Entries

activeUnit	[SimpleEntity:R-ALL-113592] ATP [cytosol]
created	[InstanceEdit:9692646] Shamovsky, Veronica, 2020-06-25
dbId	9692645
displayName	Negative regulation by '(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol]'
goBiologicalProcess	[GO_BiologicalProcess:422731] regulation of necroptotic process
regulatedEntity	[Polymerisation:R-HSA-5357927] MLKL oligomerizes - Homo sapiens
regulator	[Complex:R-HSA-9687633] (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol]
schemaClass	NegativeRegulation

(regulation)	[RegulationReference:9692647] Negative regulation by '(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol]' Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
(regulatedBy)	[Polymerisation:R-HSA-5357927] MLKL oligomerizes

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