Intracellular proteins are targeted for proteolytic degradat...

created [InstanceEdit:9625192] Varusai, Thawfeek, 2018-10-19
dbId 9625198
displayName Intracellular proteins are targeted for proteolytic degradat...
modified [InstanceEdit:9634155] Varusai, Thawfeek, 2019-01-07
schemaClass Summation
text Intracellular proteins are targeted for proteolytic degradation in the lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (Hspa8) acts as the constitutive chaperone that binds a KFERQ-domain containing substrate in the cytosol. Consequently, the substrate:HSPA8 complex translocates from cytosol to lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (Lamp2). Subsequently, Hspa8 is released and Heat shock protein HSP 90 binds to the lysosomal luminal end of Lamp2. This Lamp2 complex then multimerizes into a 700 kDa entity and is stabilized by the binding of Glial fibrillary acidic protein (Gfap) (Bandyopadhyay U et al. 2010). Subsequently, the substrate is unfolded and internalized into the lumen.
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