Reactome | AMPK, activated by CAMKK2-mediated phosphorylation, phosphor...

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created	[InstanceEdit:9619531] Orlic-Milacic, Marija, 2018-09-17
dbId	9619532
displayName	AMPK, activated by CAMKK2-mediated phosphorylation, phosphor...
literatureReference	[LiteratureReference:9619528] AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid ?-peptide exposure [LiteratureReference:9618904] The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of A? oligomers through Tau phosphorylation
modified	[InstanceEdit:9620236] Orlic-Milacic, Marija, 2018-09-21
schemaClass	Summation
text	AMPK, activated by CAMKK2-mediated phosphorylation, phosphorylates MAPT (Tau) on serine residues S262, S356 and S396. AMPK-mediated phosphorylation changes microtubule binding properties of MAPT and is involved in development and maintenance of dendritic spines and synaptotoxicity of beta-amyloid oligomers (Thornton et al. 2011, Mairet-Coello et al. 2013).

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