Reactome | Two isoforms of CaMKK, CAMKK1 (CaMKK alpha) and CAMKK2 (CaMK...

Schema > Summation > Entries

Two isoforms of CaMKK, CAMKK1 (CaMKK alpha) and CAMKK2 (CaMK... Show undefined attributes

created	[InstanceEdit:9619217] Orlic-Milacic, Marija, 2018-09-14
dbId	9619220
displayName	Two isoforms of CaMKK, CAMKK1 (CaMKK alpha) and CAMKK2 (CaMK...
literatureReference	[LiteratureReference:9618892] CaMKK2 kinase domain interacts with the autoinhibitory region through the N-terminal lobe including the RP insert [LiteratureReference:9618889] Visualizing dynamic interaction between calmodulin and calmodulin-related kinases via a monitoring method in live mammalian cells [LiteratureReference:9618902] Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation [LiteratureReference:9618904] The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of A? oligomers through Tau phosphorylation [LiteratureReference:9619215] Distinct immunohistochemical localization of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases in the adult rat brain [LiteratureReference:9619216] Immunohistochemical localization of Ca(2+)/calmodulin-dependent protein kinase kinase beta in the rat central nervous system [LiteratureReference:9619424] Distribution of Ca2+/calmodulin-dependent protein kinase kinase alpha in the rat central nervous system: an immunohistochemical study [LiteratureReference:9619426] Subcellular distributions of rat CaM kinase phosphatase N and other members of the CaM kinase regulatory system
modified	[InstanceEdit:9619427] Orlic-Milacic, Marija, 2018-09-17
schemaClass	Summation
text	Two isoforms of CaMKK, CAMKK1 (CaMKK alpha) and CAMKK2 (CaMKK beta) are expressed in the brain and involved in signaling downstream of the NMDA receptor (Schmitt et al. 2005, Mairet-Coello et al. 2013). CAMKK1 (Lee et al. 2010) and CAMKK2 (Kylarova et al. 2018) become catalytically active upon binding to the calcium-bound calmodulin (CALM1:4xCa2+). CAMKK1 and CAMKK2 localize to both cytosol and nucleus (Nakamura et al. 1996, Sakagami et al. 2000, Nakamura et al. 2001, Kitani et al. 2003).

Referrals

(summation)

[Reaction:R-HSA-9619214] CaMKK binds activated calmodulin in the cytosol

© 2026 Reactome

Cite Us!