During the process of peripheral nerve myelination, EGR2 exp...

created [InstanceEdit:9614306] Rothfels, Karen, 2018-07-24
dbId 9614307
displayName During the process of peripheral nerve myelination, EGR2 exp...
modified [InstanceEdit:9622008] Rothfels, Karen, 2018-09-28
schemaClass Summation
text During the process of peripheral nerve myelination, EGR2 expression is controlled by a feedforward transcriptional program initiated by SOX10 and maintained by POU3F2, PU3F1 and EGR2 itself (reviewed in Svaren and Meijer, 2008). Expression of EGR2 during the myelination process is controlled by a myelinating Schwann cell enhancer (MSE) 35 kb downstream of the gene (Ghislain et al, 2002). The MSE is bound by SOX10, POU3F1 and POU3F2 (Ghislain and Charnay, 2006; Reiprich et al, 2010). SOX10 in turn recruits SMARCA4, HDAC1 and HDAC2 to play overlapping but non-redundant roles in activating EGR2 expression (Jacob et al, 2011; Chen et al, 2011; Weider et al, 2012).
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