The perilipin 1 (PLIN1) gene is transcribed to yield mRNA an...

created [InstanceEdit:9608047] Shamovsky, Veronica, 2018-05-08
dbId 9608049
displayName The perilipin 1 (PLIN1) gene is transcribed to yield mRNA an...
literatureReference
modified [InstanceEdit:9658380] Shamovsky, Veronica, 2019-08-13
schemaClass Summation
text The perilipin 1 (PLIN1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Liver X receptors (LXR?, NR1H2,3) up-regulate basal human adipocyte lipolysis partially through NR1H2,3 binding to the PLIN1 promoter and down-regulation of PLIN1 expression (Stenson BM et al. 2011). By selective knockdown of either NR1H2 or NR1H3, NR1H3 was found to be the major isoform mediating the lipolysis-related effects of NR1H2,3. The Reactome event of NR1H2,3-regulated expression of PLIN1 is inferred from the analogous event regulated by a synthetic NR1H2,3 agonist GW3965 (Stenson BM et al. 2011).
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