Reactome | The neurotrophic factor NTF4 (neurotrophin-4), which functio...

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created	[InstanceEdit:9026443] Orlic-Milacic, Marija, 2017-10-19
dbId	9026444
displayName	The neurotrophic factor NTF4 (neurotrophin-4), which functio...
literatureReference	[LiteratureReference:9025077] The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site [LiteratureReference:9025040] TrkB dimerization during development of the prefrontal cortex of the macaque [LiteratureReference:9026442] The trkB tyrosine protein kinase is a receptor for neurotrophin-4 [LiteratureReference:9026441] Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF
schemaClass	Summation
text	The neurotrophic factor NTF4 (neurotrophin-4), which functions as a homodimer (Robinson et al. 1999), is a ligand for the neurotrophin receptor tyrosine kinase NTRK2 (TRKB) (Klein et al. 1992, Ip et al. 1993, Ohira et al. 2001).

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