Assembly of the MICOS complex (MINOS complex) on the inner m...

created [InstanceEdit:8953620] May, Bruce, 2016-12-26
dbId 8953614
displayName Assembly of the MICOS complex (MINOS complex) on the inner m...
modified [InstanceEdit:8961780] May, Bruce, 2017-02-05
schemaClass Summation
text Assembly of the MICOS complex (MINOS complex) on the inner mitochondrial membrane appears to cause curvature of the inner membrane into the matrix to form invaginations known as cristae. The order of steps by which the MICOS complex assembles is unknown, however the MICOS complex is known to contain two subcomplexes: the MIC60 subcomplex and the MIC10 subcomplex which may associate via MIC19. The oxidation state of MIC19 regulates assembly of the MICOS complex (Sakowska et al. 2015). MIC12 is also required to couple the two subcomplexes (Zerbes et al. 2016, inferred from human QIL1 in Guarani et al. 2015). The MICOS complex transiently associates with the SAM and TOM complexes of the outer membrane to link the inner and outer membranes (Korner et al. 2012, Zerbes et al. 2012). Oligomerization of the MIC10 (homologous to MINOS10 in mammals) subunit within the MIC10 subcomplex is responsible for the actual curvature of the inner membrane (Barbot et al. 2015, Bohnert et al. 2015). Dimerization of the F1Fo ATP synthase occurs at the interior-most regions of the cristae to form the curvature at there (Paumard et al. 2002).
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