Reactome | The Dna2 endonuclease removes the initiator RNA along with s...

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dbId	69145
displayName	The Dna2 endonuclease removes the initiator RNA along with s...
literatureReference	[LiteratureReference:69146] The nuclease activity of the yeast DNA2 protein, which is related to the RecB-like nucleases, is essential in vivo. [LiteratureReference:69131] RPA governs endonuclease switching during processing of Okazaki fragments in eucaryotes.
schemaClass	Summation
text	The Dna2 endonuclease removes the initiator RNA along with several downstream deoxyribonucleotides. The cleavage of the single-stranded RNA substrate results in the disassembly of RPA and Dna2. The current data for the role of the Dna2 endonuclease has been derived from studies with yeast and Xenopus Dna2.

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