Reactome | Interleukin-24 (IL24) (and Interleukin-20 (IL20)) can activa...

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created	[InstanceEdit:6804715] Jupe, Steve, 2015-10-14
dbId	6804714
displayName	Interleukin-24 (IL24) (and Interleukin-20 (IL20)) can activa...
literatureReference	[LiteratureReference:448707] Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types [LiteratureReference:448739] Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions
modified	[InstanceEdit:9011370] Jupe, Steve, 2017-06-30
schemaClass	Summation
text	Interleukin-24 (IL24) (and Interleukin-20 (IL20)) can activate a complex that consists of Interleukin-22 receptor subunit alpha-1 (IL22RA1), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor B (IL20RB) (Dumoutier et al. 2001, Parrish-Novak et al. 2002). As it is not clear whether the receptor can form in the absence of ligand, association of the ligand with the receptor trimer is represented here as an uncertain event.

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