STEAP3 (TSAP6) forms a complex with a pro-apoptotic protein ...

created [InstanceEdit:6801197] Orlic-Milacic, Marija, 2015-09-30
dbId 6801196
displayName STEAP3 (TSAP6) forms a complex with a pro-apoptotic protein ...
modified [InstanceEdit:8856075] Orlic-Milacic, Marija, 2016-02-08
schemaClass Summation
text STEAP3 (TSAP6) forms a complex with a pro-apoptotic protein BNIP3L (NIX) and cooperates with BNIP3L in promoting apoptosis, but the exact mechanism is not known (Passer et al. 2003).

While STEAP3 localizes to endosome membranes, BNIP3L localizes to the outer mitochondrial membrane. BNIP3L has recently been implicated in the relocalization of endo-lysosomes to inner mitochondrial compartments, which can play a role in endo-lysosomal processing of mitochondria (Hamacher-Brady et al. 2014).

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