Reactome | MSH3 forms a heterodimer with MSH2 to form the MSH3:MSH2 com...

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created	[InstanceEdit:5633022] Gillespie, Marc E, 2014-10-29
dbId	5633024
displayName	MSH3 forms a heterodimer with MSH2 to form the MSH3:MSH2 com...
literatureReference	[LiteratureReference:5578670] Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair [LiteratureReference:5358962] Mismatch repair deficiency associated with overexpression of the MSH3 gene
schemaClass	Summation
text	MSH3 forms a heterodimer with MSH2 to form the MSH3:MSH2 complex, part of the post-replicative DNA mismatch repair system. This complex initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. Defects in this gene are a cause of susceptibility to endometrial cancer.

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