DDIT4 (REDD1) binds 14-3-3 proteins through a conserved 14-3...

created [InstanceEdit:5632743] Orlic-Milacic, Marija, 2014-10-28
dbId 5632744
displayName DDIT4 (REDD1) binds 14-3-3 proteins through a conserved 14-3...
schemaClass Summation
text DDIT4 (REDD1) binds 14-3-3 proteins through a conserved 14-3-3 binding motif Arg-X-X-X-Ser/Thr-X-Pro (DeYoung et al. 2008). Binding of DDIT4 to 14-3-3 proteins competes with 14-3-3 binding to TSC2 and thus prevents AKT-mediated inactivation of TSC2 (Cam et al. 2014).
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