Reactome | CD209 (DC-SIGN) interacts with pathogens through either mann...

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created	[InstanceEdit:5621584] Garapati, P V, 2014-09-01
dbId	5621600
displayName	CD209 (DC-SIGN) interacts with pathogens through either mann...
literatureReference	[LiteratureReference:5607189] C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB [LiteratureReference:5621576] Mycobacteria target DC-SIGN to suppress dendritic cell function [LiteratureReference:5607468] Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk
modified	[InstanceEdit:5663011] Garapati, P V, 2015-01-14
schemaClass	Summation
text	CD209 (DC-SIGN) interacts with pathogens through either mannose or fucose containing glycans. It interacts with mannose capped cell-wall component of Mycobacterium tuberculosis ManLAM (lipoarabinomannan). The carbohydrate recognition domain (CRD) of CD209 recognizes Man-LAM and lipomannans and the amount of Man-LAM determines the binding strength. The interaction of ManLAM and CD209 leads to the activation of serine/threonine kinase RAF1 and increases the production of the immunosuppressive cytokine interleukin 6 (IL6), IL10 and IL12 in the presence of Toll like receptor stimulation (Geijtenbeek et al. 2003, Gringhuis et al. 2007 & 2009).

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