The proline-rich tyrosine kinase 2 (PYK2) is a nonreceptor p...

created [InstanceEdit:508514] Jupe, S, 2010-02-12
dbId 508511
displayName The proline-rich tyrosine kinase 2 (PYK2) is a nonreceptor p...
literatureReference
modified [InstanceEdit:1213522] Jupe, S, 2011-02-11
schemaClass Summation
text The proline-rich tyrosine kinase 2 (PYK2) is a nonreceptor protein tyrosine kinase that is structurally related to FAK and thought to be important for leukocyte activation (Ostergaard & Lysechko 2005).
Coimmunoprecipitation experiments have demonstrated a physical association of Jak3 and Pyk2. A dominant interfering mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation. Collectively, these results suggest that Pyk2 is a component of the Jak-mediated IL-2 signaling pathway, but a role has not been firmly established.
Cite Us!