Reactome | PTPN11 (SHP2) is recruited to the phosphorylated UNC5C recep...

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created	[InstanceEdit:418739] Garapati, P V, 2009-04-27 08:54:58
dbId	418759
displayName	PTPN11 (SHP2) is recruited to the phosphorylated UNC5C recep...
literatureReference	[LiteratureReference:418743] Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain
modified	[InstanceEdit:9605563] Orlic-Milacic, Marija, 2018-04-13
schemaClass	Summation
text	PTPN11 (SHP2) is recruited to the phosphorylated UNC5C receptor after netrin-1 (NTN1) stimulation, in a fashion that requires binding of the PTPN11 SH2 domains to the Tyr568 (Y568) phosphorylated motif. The functional significance of the UNC5C- PTPN11 interaction has not been reported. PTPN11 might negatively regulate tyrosine phosphorylation of UNC5C receptor, facilitating resensitization of the receptor to the netrin-1 signal.

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