Reactome | gain_of_function via non_conservative_missense

Schema > FunctionalStatus > Entries

gain_of_function via non_conservative_missense_variant Show undefined attributes

created	[InstanceEdit:2362352] Orlic-Milacic, M, 2012-06-26
dbId	2362351
displayName	gain_of_function via non_conservative_missense_variant
functionalStatusType	[FunctionalStatusType:2426108] gain_of_function
modified	[InstanceEdit:5666988] Jupe, Steve, 2015-01-22
schemaClass	FunctionalStatus
structuralVariant	[SequenceOntology:2318481] non_conservative_missense_variant

Referrals

(functionalStatus)

[EntityFunctionalStatus:9687802] gain_of_function of F12 variant (329-615) [extracellular region]
[EntityFunctionalStatus:9653254] gain_of_function of F12 variant [extracellular region]
[EntityFunctionalStatus:9824839] gain_of_function of C-ter TLR7 variant dimer [endolysosome membrane]
[EntityFunctionalStatus:5603047] gain_of_function of NFKBIA variants [cytosol]
[EntityFunctionalStatus:5683224] gain_of_function of ABCC8 mutants (PNDM, TNDM2) [plasma membrane]
[EntityFunctionalStatus:5637727] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane]
[EntityFunctionalStatus:5637720] gain_of_function of Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:5637724] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane]
[EntityFunctionalStatus:5637731] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]
[EntityFunctionalStatus:5637726] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane]
[EntityFunctionalStatus:5637719] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane]
[EntityFunctionalStatus:5637730] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:5637725] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane]
[EntityFunctionalStatus:5637722] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane]
[EntityFunctionalStatus:5637729] gain_of_function of EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:5637721] gain_of_function of Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:5637732] gain_of_function of Active dimers of ligand-responsive EGFR mutants [plasma membrane]
[EntityFunctionalStatus:5637728] gain_of_function of Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane]
[EntityFunctionalStatus:5637718] gain_of_function of Ligand-responsive EGFR mutants [plasma membrane]
[EntityFunctionalStatus:9630141] gain_of_function of NOTCH1 HD domain mutants/Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane]
[EntityFunctionalStatus:9630144] gain_of_function of DLL/JAG:NOTCH1 HD domain mutants [plasma membrane]
[EntityFunctionalStatus:9631997] gain_of_function of NOTCH1 HD domain mutants [plasma membrane]
[EntityFunctionalStatus:2711103] gain_of_function of NOTCH1 HD domain mutants [plasma membrane]
[EntityFunctionalStatus:9632007] gain_of_function of NOTCH1 HD+PEST Domain Mutants [plasma membrane]
[EntityFunctionalStatus:2900744] gain_of_function of NOTCH1 HD+PEST Domain Mutants [plasma membrane]
[EntityFunctionalStatus:9630147] gain_of_function of DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
[EntityFunctionalStatus:9630138] gain_of_function of NOTCH1 HD+PEST Domain Mutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
[EntityFunctionalStatus:9674448] gain_of_function of type II TKI sensitive PDGFR mutants [plasma membrane]
[EntityFunctionalStatus:9674446] gain_of_function of type I TKI sensitive PDGFR mutants [plasma membrane]
[EntityFunctionalStatus:9672154] gain_of_function of extracellular domain mutant PDGFRA dimers [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9672145] gain_of_function of p-11Y PDGFRA extracellular domain dimers:PI3K [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9672152] gain_of_function of p-11Y PDGFRA extracellular domain dimers [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9673665] gain_of_function of PDGFRA extracellular domain mutants [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9672156] gain_of_function of extracellular domain mutant PDGFRA dimers [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9672148] gain_of_function of p-11Y PDGFRA extracellular domain dimers [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9672153] gain_of_function of p-11Y PDGFRA extracellular domain dimers:GRB2:SOS1 [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9672146] gain_of_function of p-11Y PDGFR mutatnt receptors:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9672149] gain_of_function of p-11Y PDGFR mutant receptor dimers [plasma membrane]
[EntityFunctionalStatus:9672151] gain_of_function of p-11Y PDGFR mutant receptor dimers [plasma membrane]
[EntityFunctionalStatus:9672155] gain_of_function of PDGFR mutant receptors [plasma membrane]
[EntityFunctionalStatus:9672147] gain_of_function of PDGFR mutant dimers [plasma membrane]
[EntityFunctionalStatus:9672150] gain_of_function of p-11Y PDGFR mutant receptor dimers [plasma membrane]
[EntityFunctionalStatus:9672144] gain_of_function of p-11Y PDGFR mutant dimers:PI3K [plasma membrane]
[EntityFunctionalStatus:5362402] gain_of_function of SHH variants [endoplasmic reticulum lumen]
[EntityFunctionalStatus:9630076] gain_of_function of SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen]
[EntityFunctionalStatus:9630074] gain_of_function of SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9630078] gain_of_function of ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
[EntityFunctionalStatus:9630079] gain_of_function of ub-SHH variants [cytosol]
[EntityFunctionalStatus:2632525] gain_of_function of PI3K mutants [plasma membrane]
[EntityFunctionalStatus:2400003] gain_of_function of p-T308,S473-AKT1 E17K [nucleoplasm]
[EntityFunctionalStatus:3080615] gain_of_function of p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
[EntityFunctionalStatus:3080614] gain_of_function of PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
[EntityFunctionalStatus:2400002] gain_of_function of p-T308,S473-AKT1 E17K [cytosol]
[EntityFunctionalStatus:2362350] gain_of_function of AKT1 E17K [cytosol]
[EntityFunctionalStatus:3080617] gain_of_function of AKT1 E17K mutant:PIP2 [plasma membrane]
[EntityFunctionalStatus:9665450] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9665462] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane]
[EntityFunctionalStatus:9665440] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1 [plasma membrane]
[EntityFunctionalStatus:9665439] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9665438] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane]
[EntityFunctionalStatus:9665435] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:SHC1 [plasma membrane]
[EntityFunctionalStatus:9665378] gain_of_function of ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9665387] gain_of_function of ERBB2 ECD mutants:EGF:EGFR [plasma membrane]
[EntityFunctionalStatus:9665448] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane]
[EntityFunctionalStatus:9665451] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane]
[EntityFunctionalStatus:9665461] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:GAB1:PI3K [plasma membrane]
[EntityFunctionalStatus:9664938] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1:PI3K [plasma membrane]
[EntityFunctionalStatus:9665042] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane]
[EntityFunctionalStatus:9665038] gain_of_function of p-6Y-ERBB2 KD mutants (PLCG1):EGF:p-6Y-EGFR [plasma membrane]
[EntityFunctionalStatus:9664931] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane]
[EntityFunctionalStatus:9664989] gain_of_function of Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9664669] gain_of_function of p-ERBB2 KD mutants:NRG1/NRG2:p-10Y-ERBB3 [plasma membrane]
[EntityFunctionalStatus:9664668] gain_of_function of p-ERBB2 KD mutants:NRG1/NRG2:p-10Y-ERBB3:PI3K [plasma membrane]
[EntityFunctionalStatus:9664928] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR [plasma membrane]
[EntityFunctionalStatus:9664980] gain_of_function of Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1 [plasma membrane]
[EntityFunctionalStatus:9664951] gain_of_function of Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane]
[EntityFunctionalStatus:9664971] gain_of_function of Phosphorylated heterodimers of ERBB2 KD mutants:SHC1 [plasma membrane]
[EntityFunctionalStatus:9664569] gain_of_function of ERBB2 KD mutants:ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9664607] gain_of_function of Heterodimers of ERBB2 KD mutants [plasma membrane]
[EntityFunctionalStatus:9664998] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR [plasma membrane]
[EntityFunctionalStatus:9665011] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9665926] gain_of_function of p-6Y-ERBB2 R678Q:EGF:p-6Y-EGFR:PLCG1 [plasma membrane]
[EntityFunctionalStatus:9665923] gain_of_function of p-6Y-ERBB2 R678Q:EGF:p-6Y-EGFR [plasma membrane]
[EntityFunctionalStatus:9665914] gain_of_function of p-6Y-ERBB2 TMD/JMD mutants (RAS):EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9665868] gain_of_function of p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9820554] gain_of_function of ERBB2 TMD/JMD mutants (TKI sensitive):ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9820556] gain_of_function of ERBB2 R678Q:ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9820555] gain_of_function of ERBB2 TMD/JMD mutants (trastuzumab):ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9665918] gain_of_function of p-6Y-ERBB2 TMD/JMD mutants (RAS):EGF:p-6Y-EGFR [plasma membrane]
[EntityFunctionalStatus:9665889] gain_of_function of ERBB2 TMD/JMD mutants:ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9665886] gain_of_function of ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane]
[EntityFunctionalStatus:9665883] gain_of_function of p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane]
[EntityFunctionalStatus:9665872] gain_of_function of p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):SHC1 [plasma membrane]
[EntityFunctionalStatus:9665873] gain_of_function of p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1 [plasma membrane]
[EntityFunctionalStatus:9698200] gain_of_function of p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9698198] gain_of_function of p-6Y FLT3 mutant dimers:GRB2 [plasma membrane]
[EntityFunctionalStatus:9695835] gain_of_function of FLT3 extracellular domain, kinase domain and juxtamembrane domain mutants [plasma membrane]
[EntityFunctionalStatus:9698197] gain_of_function of p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane]
[EntityFunctionalStatus:9698184] gain_of_function of p-6Y FLT3 mutant dimers:GRB2 [plasma membrane]
[EntityFunctionalStatus:9680251] gain_of_function of extracellular domain mutant dimers of KIT [plasma membrane]
[EntityFunctionalStatus:9680254] gain_of_function of extracellular domain mutants of KIT [plasma membrane]
[EntityFunctionalStatus:9670397] gain_of_function of p-JAK2:SFKs:p-KIT mutants:p-STAT dimers [plasma membrane]
[EntityFunctionalStatus:9670400] gain_of_function of p-KIT mutants:GRB2:SOS [plasma membrane]
[EntityFunctionalStatus:9670390] gain_of_function of KIT mutant dimers:SFKs:p-JAK2 [plasma membrane]
[EntityFunctionalStatus:9670393] gain_of_function of KIT mutant dimers:SFKs:p-JAK2:STATs [plasma membrane]
[EntityFunctionalStatus:9670398] gain_of_function of p-JAK2:SFKs:p-KIT mutants:p-STATs [plasma membrane]
[EntityFunctionalStatus:9670395] gain_of_function of PI3K:p-KIT mutant dimers [plasma membrane]
[EntityFunctionalStatus:9669905] gain_of_function of juxtamembrane domain KIT mutants [plasma membrane]
[EntityFunctionalStatus:9669908] gain_of_function of juxtamembrane domain KIT mutant dimers [plasma membrane]
[EntityFunctionalStatus:9669889] gain_of_function of kinase domain KIT mutants [plasma membrane]
[EntityFunctionalStatus:9670402] gain_of_function of p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane]
[EntityFunctionalStatus:9670386] gain_of_function of KIT mutant dimers:SFKs [plasma membrane]
[EntityFunctionalStatus:9670388] gain_of_function of KIT mutant dimers:SFKs:JAK2 [plasma membrane]
[EntityFunctionalStatus:9669902] gain_of_function of type II TKI sensitive KIT mutants [plasma membrane]
[EntityFunctionalStatus:9669897] gain_of_function of type TKI sensitive KIT mutants [plasma membrane]
[EntityFunctionalStatus:9686617] gain_of_function of ripretinib-sensitive KIT mutants [plasma membrane]
[EntityFunctionalStatus:5655310] gain_of_function of Activated FGFR4 mutants:p-4Y-PLCG1 [plasma membrane]
[EntityFunctionalStatus:5655281] gain_of_function of Activated FGFR4 mutants:PLCG1 [plasma membrane]
[EntityFunctionalStatus:5655325] gain_of_function of Activated FGFR4 mutants:p-FRS2 [plasma membrane]
[EntityFunctionalStatus:5655300] gain_of_function of Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
[EntityFunctionalStatus:5655317] gain_of_function of FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:5654466] gain_of_function of FGFR4 Y367C mutant dimer [plasma membrane]
[EntityFunctionalStatus:5654481] gain_of_function of FGFR4 Y367C [plasma membrane]
[EntityFunctionalStatus:5654496] gain_of_function of FGFR4 enhanced kinase mutants [plasma membrane]
[EntityFunctionalStatus:5654468] gain_of_function of FGFR4 enhanced kinase mutant dimers [plasma membrane]
[EntityFunctionalStatus:5655309] gain_of_function of Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
[EntityFunctionalStatus:9632003] gain_of_function of Activated FGFR4 mutants:p-FRS2 [plasma membrane]
[EntityFunctionalStatus:5655322] gain_of_function of Activated FGFR4 mutants:FRS2 [plasma membrane]
[EntityFunctionalStatus:5655335] gain_of_function of Activated FGFR4 mutants [plasma membrane]
[EntityFunctionalStatus:5655292] gain_of_function of FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9632015] gain_of_function of Activated FGFR2 mutants:p-FRS2 [plasma membrane]
[EntityFunctionalStatus:5655283] gain_of_function of Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
[EntityFunctionalStatus:5655288] gain_of_function of Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
[EntityFunctionalStatus:5654744] gain_of_function of Activated FGFR2 mutants:p-4Y-PLCG1 [plasma membrane]
[EntityFunctionalStatus:5654539] gain_of_function of FGFR2 point mutant dimers [plasma membrane]
[EntityFunctionalStatus:5654454] gain_of_function of FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane]
[EntityFunctionalStatus:5654449] gain_of_function of FGFR2 ligand-independent mutant dimers [plasma membrane]
[EntityFunctionalStatus:5654452] gain_of_function of FGFR2 mutant dimers with enhanced kinase activity [plasma membrane]
[EntityFunctionalStatus:5654518] gain_of_function of FGFR2b mutants with enhanced ligand binding [plasma membrane]
[EntityFunctionalStatus:5654489] gain_of_function of FGFR2 mutants with enhanced kinase activity [plasma membrane]
[EntityFunctionalStatus:5654520] gain_of_function of FGFR2c mutants with enhanced ligand binding [plasma membrane]
[EntityFunctionalStatus:5654457] gain_of_function of FGFR2c mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane]
[EntityFunctionalStatus:5654488] gain_of_function of FGFR2 ligand-independent mutants [plasma membrane]
[EntityFunctionalStatus:5655334] gain_of_function of Activated FGFR2 mutants [plasma membrane]
[EntityFunctionalStatus:5655327] gain_of_function of Activated FGFR2 mutants:p-FRS2 [plasma membrane]
[EntityFunctionalStatus:5655246] gain_of_function of Activated FGFR2 mutants:PLCG1 [plasma membrane]
[EntityFunctionalStatus:5655264] gain_of_function of Activated FGFR2 mutants:FRS2 [plasma membrane]
[EntityFunctionalStatus:5655286] gain_of_function of Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
[EntityFunctionalStatus:5655261] gain_of_function of FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9757294] gain_of_function of Activated FGFR3 point and translocation mutants [plasma membrane]
[EntityFunctionalStatus:5655260] gain_of_function of Activated FGFR3 point and translocation mutants: PLCG1 [plasma membrane]
[EntityFunctionalStatus:5655338] gain_of_function of Activated FGFR3 point and translocation mutants:p-4Y-PLCG1 [plasma membrane]
[EntityFunctionalStatus:5655314] gain_of_function of Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane]
[EntityFunctionalStatus:5655276] gain_of_function of Activated FGFR3 point, translocation and fusion mutants [plasma membrane]
[EntityFunctionalStatus:9632023] gain_of_function of Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane]
[EntityFunctionalStatus:5654459] gain_of_function of FGFR3 cysteine mutant dimers [plasma membrane]
[EntityFunctionalStatus:5654478] gain_of_function of FGFR3 cysteine mutants [plasma membrane]
[EntityFunctionalStatus:5654464] gain_of_function of FGFR3c P250R mutant dimer bound to FGF [plasma membrane]
[EntityFunctionalStatus:5654524] gain_of_function of FGFR3c P250R [plasma membrane]
[EntityFunctionalStatus:5654492] gain_of_function of FGFR3 point mutants with enhanced kinase activity [plasma membrane]
[EntityFunctionalStatus:5654461] gain_of_function of FGFR3 point mutant dimers with enhanced kinase activity [plasma membrane]
[EntityFunctionalStatus:5654493] gain_of_function of FGFR3 (4;14) translocation mutants [plasma membrane]
[EntityFunctionalStatus:5654462] gain_of_function of FGFR3 (4;14) translocation mutant dimers [plasma membrane]
[EntityFunctionalStatus:5654521] gain_of_function of FGFR3 mutant dimers [plasma membrane]
[EntityFunctionalStatus:5655306] gain_of_function of Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
[EntityFunctionalStatus:5655239] gain_of_function of Activated FGFR3 point, translocation and fusion mutants:FRS2 [plasma membrane]
[EntityFunctionalStatus:5655220] gain_of_function of Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
[EntityFunctionalStatus:9632021] gain_of_function of Activated FGFR1 mutants:p-FRS2 [plasma membrane]
[EntityFunctionalStatus:5655349] gain_of_function of Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
[EntityFunctionalStatus:5655293] gain_of_function of FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:5654486] gain_of_function of FGFR1 mutants with enhanced kinase activity [plasma membrane]
[EntityFunctionalStatus:6803231] gain_of_function of mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]
[EntityFunctionalStatus:6802893] gain_of_function of mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane]
[EntityFunctionalStatus:6802891] gain_of_function of mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane]
[EntityFunctionalStatus:6802867] gain_of_function of RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane]
[EntityFunctionalStatus:6802864] gain_of_function of RAS mutants:GTP:RAF homo/heterodimer [plasma membrane]
[EntityFunctionalStatus:6802863] gain_of_function of RAS mutants:GTP [plasma membrane]
[EntityFunctionalStatus:6803239] gain_of_function of RAS mutants:GTP:RAF [plasma membrane]
[EntityFunctionalStatus:6802883] gain_of_function of high kinase activity BRAF mutants [cytosol]
[EntityFunctionalStatus:6802885] gain_of_function of high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol]
[EntityFunctionalStatus:6802887] gain_of_function of high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol]
[EntityFunctionalStatus:6803226] gain_of_function of high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol]
[EntityFunctionalStatus:6802877] gain_of_function of RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane]
[EntityFunctionalStatus:6802874] gain_of_function of RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane]
[EntityFunctionalStatus:6802872] gain_of_function of RAS:GTP:moderate kinase activity BRAF mutants:RAF:YWHAB [plasma membrane]
[EntityFunctionalStatus:6802888] gain_of_function of moderate kinase activity BRAF mutants [cytosol]
[EntityFunctionalStatus:6803228] gain_of_function of RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]
[EntityFunctionalStatus:6802879] gain_of_function of RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane]
[EntityFunctionalStatus:8936673] gain_of_function of p21 RAS:GTP:moderate kinase activity BRAF mutants [plasma membrane]
[EntityFunctionalStatus:9652162] gain_of_function of MAP2K1 and MAP2K2 mutants [cytosol]
[EntityFunctionalStatus:9660501] gain_of_function of mutant MRAS:SHOC2:PP1 complexes [plasma membrane]
[EntityFunctionalStatus:6802869] gain_of_function of RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane]
[EntityFunctionalStatus:8936728] gain_of_function of chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane]
[EntityFunctionalStatus:6802880] gain_of_function of genetically or chemically inactive BRAF [cytosol]
[EntityFunctionalStatus:6803235] gain_of_function of RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]
[EntityFunctionalStatus:6802871] gain_of_function of RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane]
[EntityFunctionalStatus:6802897] gain_of_function of mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane]
[EntityFunctionalStatus:6802894] gain_of_function of mutant RAS:inactive BRAF:RAF1 [plasma membrane]
[EntityFunctionalStatus:9656204] gain_of_function of p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane]
[EntityFunctionalStatus:9656202] gain_of_function of p21 RAS:GTP:RAF1 mutant heterodimers [plasma membrane]
[EntityFunctionalStatus:9656194] gain_of_function of RAF1 mutants [cytosol]
[EntityFunctionalStatus:9656200] gain_of_function of activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]
[EntityFunctionalStatus:9656199] gain_of_function of activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
[EntityFunctionalStatus:9656196] gain_of_function of activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane]
[EntityFunctionalStatus:5666989] gain_of_function of JAK2 V617F [nucleoplasm]
[EntityFunctionalStatus:9844228] gain_of_function of GP1BA variant:GP1BB:GP9:GP5 [plasma membrane]
[EntityFunctionalStatus:9844236] gain_of_function of Collagen type I fibril:VWF variant multimer [extracellular region]
[EntityFunctionalStatus:9670057] gain_of_function of factor VIIIa with defective A1 domain [extracellular region]
[EntityFunctionalStatus:9670056] gain_of_function of factor VIIIa with defective A2 domain [extracellular region]
[EntityFunctionalStatus:9668252] gain_of_function of FVIIIa:FIXa R384L [plasma membrane]
[EntityFunctionalStatus:5654508] gain_of_function of Activated FGFR1 mutants and fusions [plasma membrane]
[EntityFunctionalStatus:5655258] gain_of_function of Activated FGFR1 mutants [plasma membrane]
[EntityFunctionalStatus:5655256] gain_of_function of Activated FGFR1 mutants:p-FRS2 [plasma membrane]
[EntityFunctionalStatus:5655333] gain_of_function of Activated FGFR1 mutants:FRS2 [plasma membrane]
[EntityFunctionalStatus:5654445] gain_of_function of FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]
[EntityFunctionalStatus:5654502] gain_of_function of FGFR1c P252X mutants [plasma membrane]
[EntityFunctionalStatus:5654448] gain_of_function of FGFR1 mutant dimers with enhanced kinase activity [plasma membrane]

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