Reactome | M1 protein binds to viral RNP through its C-terminal domain ...

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created	[InstanceEdit:192697] Gillespie, ME, 2007-02-07 04:51:41
dbId	192671
displayName	M1 protein binds to viral RNP through its C-terminal domain ...
literatureReference	[LiteratureReference:192904] Association of influenza virus matrix protein with ribonucleoproteins may control viral growth and morphology [LiteratureReference:169004] Effect of influenza virus matrix protein and viral RNA on ribonucleoprotein formation and nuclear export [LiteratureReference:192743] Association of influenza virus matrix protein with ribonucleoproteins [LiteratureReference:192639] Role of the influenza virus M1 protein in nuclear export of viral ribonucleoproteins [LiteratureReference:192927] Heat shock protein 70 is related to thermal inhibition of nuclear export of the influenza virus ribonucleoprotein complex
schemaClass	Summation
text	M1 protein binds to viral RNP through its C-terminal domain (Baudin, 2001). The influenza M1 protein accumulates in the infected cell nucleus through a nuclear localization signal (NLS) RKLKR (residues 101-105) in its N-terminus (Ye, 1999). A host cell protein, HSP70, is thought to inhibit M1 binding at nonpermissive temperatures (Hirayama et al., 2004).

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