Reactome | metallopeptidase activity of ADAM10/17:Zn2+ [plasma membrane]

Schema > CatalystActivity > Entries

activity	[GO_MolecularFunction:1795] metallopeptidase activity
catalyzedEvent	[Reaction:R-HSA-2730752] NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding - Homo sapiens [Reaction:R-HSA-2220944] ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants - Homo sapiens [Reaction:R-HSA-2220976] NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding - Homo sapiens [Reaction:R-HSA-2666278] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 - Homo sapiens [Reaction:R-HSA-157632] Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 - Homo sapiens
created	[InstanceEdit:1852618] Orlic-Milacic, M, 2011-10-28
dbId	1852619
displayName	metallopeptidase activity of ADAM10/17:Zn2+ [plasma membrane]
modified	[InstanceEdit:9689079] Cook, Justin, 2020-05-15
physicalEntity	[Complex:R-HSA-1852620] ADAM10/17:Zn2+ [plasma membrane]
schemaClass	CatalystActivity

(catalystActivity)

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