Cytosolic branched-chain-amino-acid aminotransferase (BCAT1)...

created [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
dbId 178919
displayName Cytosolic branched-chain-amino-acid aminotransferase (BCAT1)...
modified [InstanceEdit:9673821] D'Eustachio, Peter, 2020-01-09
schemaClass Summation
text Cytosolic branched-chain-amino-acid aminotransferase (BCAT1) catalyzes the reversible reactions of leucine, isoleucine, or valine with alpha-ketoglutarate (2-oxoglutarate) to form alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate, respectively, and glutamate. The active enzyme is a homodimer. Goto et al. (2005) have argued that cytosolic BCAT1 plays a major role in the generation of glutamate involved in synaptic transmission in neural tissue.
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