Cytosolic serine hydroxymethyltransferase tetramer (SHMT1) c...

created [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
dbId 178503
displayName Cytosolic serine hydroxymethyltransferase tetramer (SHMT1) c...
modified [InstanceEdit:9853456] D'Eustachio, Peter, 2023-11-15
schemaClass Summation
text Cytosolic serine hydroxymethyltransferase tetramer (SHMT1) catalyzes the reaction of (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine(1+) (NTMLYS) to form glycine (Gly) and 4-trimethylammoniobutanal (TEABL). Ogata & Fujioka (1981) and Masuda et al. (1987) purified a tetrameric cytosolic rat enzyme that in the presence of tetrahydrofolate catalyzes the conversion of serine to glycine but that in its absence catalyzes the cleavage of L-allothreonine to glycine and an aldehyde. Vaz & Wanders (2002) inferred that this enzyme and its human ortholog mediate the cleavage of HTMLYS to yield TEABL and Gly in vivo. This inference has been confirmed by computational docking studies and assays of the activity of purified recombinant human enzyme in vitro (Percudani et al. 2023).
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