Reactome | Nef amino terminal myristoylation has been shown to be criti...

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created	[InstanceEdit:167538] Gillespie, ME, 2005-10-20 18:11:21
dbId	167612
displayName	Nef amino terminal myristoylation has been shown to be criti...
literatureReference	[LiteratureReference:167510] A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity [LiteratureReference:167574] Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain [LiteratureReference:167587] Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene
modified	[InstanceEdit:184175] Gillespie, ME, 2006-07-25 18:18:23
schemaClass	Summation
text	Nef amino terminal myristoylation has been shown to be critical for many of Nef's functions. As expected myristoylated Nef can be identified as co-fractionating with cell membranes and cytoskeletal components.

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