Reactome | Plasminogen reversibly binds histidine-rich glycoprotein (HR...

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created	[InstanceEdit:158720] D'Eustachio, P, 2005-02-05 20:25:20
dbId	158719
displayName	Plasminogen reversibly binds histidine-rich glycoprotein (HR...
literatureReference	[LiteratureReference:158716] Isolation and characterization of a human plasma protein with affinity for the lysine binding sites in plasminogen. Role in the regulation of fibrinolysis and identification as histidine-rich glycoprotein. [LiteratureReference:158715] HRG Tokushima: molecular and cellular characterization of histidine-rich glycoprotein (HRG) deficiency
modified	[InstanceEdit:158898] D'Eustachio, P, 2005-02-10 21:54:28
schemaClass	Summation
text	Plasminogen reversibly binds histidine-rich glycoprotein (HRG). The resulting complex interacts poorly with fibrin, suggesting that HRG might have an anti-fibrinolytic (clot-stabilizing) effect in vivo (Lijnen et al. 1980). Consistent with this suggestion, individuals with chronically reduced plasma HRG concentrations are susceptible to thrombosis (Shigekiyo et al. 1998).

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