N-acetylglucosaminyltransferase (GnT)-IV catalyzes the addit...

created [InstanceEdit:1015777] Jassal, B, 2010-11-15
dbId 1015749
displayName N-acetylglucosaminyltransferase (GnT)-IV catalyzes the addit...
modified [InstanceEdit:1015797] Jassal, B, 2010-11-15
schemaClass Summation
text N-acetylglucosaminyltransferase (GnT)-IV catalyzes the addition of GlcNAc beta,1,4 on the GlcNAc beta1,2 Man,alpha1,3 arm of both complex and hybrid N-glycans (Oguri S et al, 2006). Two human GnT-IV isozymes have been characterized (MGAT4A, MGAT4B) , plus a putative MGAT4C on chromosome 2 (Furukawa T et al, 1999). Aberrant expression of MGAT4A or MGAT4B is associated with pancreatic cancer (Ide Y et al, 2006; Kudo T et al , 2007)
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