Reactome | rfc2 [nucleoplasm]

rfc2 [nucleoplasm]

Stable Identifier

R-XTR-68433

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

RFC2, B4F6H8

Locations in the PathwayBrowser

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Cell Cycle (Xenopus tropicalis)

- Cell Cycle Checkpoints (Xenopus tropicalis)
  - G2/M Checkpoints (Xenopus tropicalis)
    - Activation of ATR in response to replication stress (Xenopus tropicalis)
      - Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Xenopus tropicalis)
        
        Rad17-RFC complex bound to DNA [nucleoplasm] (Xenopus tropicalis)
        
        RAD17:RFC [nucleoplasm] (Xenopus tropicalis)
        
        rfc2 [nucleoplasm] (Xenopus tropicalis)
        
        Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Xenopus tropicalis)
        
        Rad17-RFC complex bound to DNA [nucleoplasm] (Xenopus tropicalis)
        
        RAD17:RFC [nucleoplasm] (Xenopus tropicalis)
        
        rfc2 [nucleoplasm] (Xenopus tropicalis)

DNA Repair (Xenopus tropicalis)

- DNA Damage Bypass (Xenopus tropicalis)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Xenopus tropicalis)
    - Translesion Synthesis by POLH (Xenopus tropicalis)
      - SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Xenopus tropicalis)
        
        NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        RFC Heteropentamer [nucleoplasm] (Xenopus tropicalis)
        
        rfc2 [nucleoplasm] (Xenopus tropicalis)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        RFC Heteropentamer [nucleoplasm] (Xenopus tropicalis)
        
        rfc2 [nucleoplasm] (Xenopus tropicalis)
      - SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Xenopus tropicalis)
        
        NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        RFC Heteropentamer [nucleoplasm] (Xenopus tropicalis)
        
        rfc2 [nucleoplasm] (Xenopus tropicalis)
        
        NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA [nucleoplasm] (Xenopus tropicalis)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        RFC Heteropentamer [nucleoplasm] (Xenopus tropicalis)
        
        rfc2 [nucleoplasm] (Xenopus tropicalis)
    - Translesion synthesis by POLI (Xenopus tropicalis)
      - POLI incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)
        
        POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        RFC Heteropentamer [nucleoplasm] (Xenopus tropicalis)
        
        rfc2 [nucleoplasm] (Xenopus tropicalis)
        
        POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        RFC Heteropentamer [nucleoplasm] (Xenopus tropicalis)
        
        rfc2 [nucleoplasm] (Xenopus tropicalis)
- Nucleotide Excision Repair (Xenopus tropicalis)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Xenopus tropicalis)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Xenopus tropicalis)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Xenopus tropicalis)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        RFC Heteropentamer [nucleoplasm] (Xenopus tropicalis)
        
        rfc2 [nucleoplasm] (Xenopus tropicalis)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        RFC Heteropentamer [nucleoplasm] (Xenopus tropicalis)
        
        rfc2 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:B4F6H8

Gene Names

rfc2

Reference Genes

BioGPS Gene:100216026 rfc2

ENSEMBL:ENSXETG00000018234

KEGG:xtr:100216026 rfc2

Monarch:100216026 rfc2

NCBI Gene:100216026 rfc2

UCSC:B4F6H8 rfc2

Reference Transcript

RefSeq:NM_001142016.1 rfc2

Participates

as a component of

Inferred From

RFC2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001135488.1

Xenbase

XB-GENE-999114

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