Reactome | pik3r6 [cytosol]

pik3r6 [cytosol]

Stable Identifier

R-XTR-425642

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

PIK3R6, F6RLH3

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Regulation of T cell activation by CD28 family (Xenopus tropicalis)
    - Co-stimulation by CD28 (Xenopus tropicalis)
      - CD28 dependent PI3K/Akt signaling (Xenopus tropicalis)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
        
        CD28:PI3K [plasma membrane] (Xenopus tropicalis)
        
        Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        PI3K gamma [cytosol] (Xenopus tropicalis)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Xenopus tropicalis)
        
        pik3r6 [cytosol] (Xenopus tropicalis)
        
        PI3K binds CD28 (Xenopus tropicalis)
        
        CD28:PI3K [plasma membrane] (Xenopus tropicalis)
        
        Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        PI3K gamma [cytosol] (Xenopus tropicalis)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Xenopus tropicalis)
        
        pik3r6 [cytosol] (Xenopus tropicalis)
        
        Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        PI3K gamma [cytosol] (Xenopus tropicalis)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Xenopus tropicalis)
        
        pik3r6 [cytosol] (Xenopus tropicalis)
    - Co-stimulation by ICOS (Xenopus tropicalis)
      - PI3K binds ICOS (Xenopus tropicalis)
        
        Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        PI3K gamma [cytosol] (Xenopus tropicalis)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Xenopus tropicalis)
        
        pik3r6 [cytosol] (Xenopus tropicalis)
        
        ICOS:PI3K [plasma membrane] (Xenopus tropicalis)
        
        Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        PI3K gamma [cytosol] (Xenopus tropicalis)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Xenopus tropicalis)
        
        pik3r6 [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Intracellular signaling by second messengers (Xenopus tropicalis)
  - PIP3 activates AKT signaling (Xenopus tropicalis)
    - Negative regulation of the PI3K/AKT network (Xenopus tropicalis)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Xenopus tropicalis)
        
        PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
        
        Activator:PI3K [plasma membrane] (Xenopus tropicalis)
        
        CD28:PI3K [plasma membrane] (Xenopus tropicalis)
        
        Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        PI3K gamma [cytosol] (Xenopus tropicalis)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Xenopus tropicalis)
        
        pik3r6 [cytosol] (Xenopus tropicalis)
        
        ICOS:PI3K [plasma membrane] (Xenopus tropicalis)
        
        Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        PI3K gamma [cytosol] (Xenopus tropicalis)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Xenopus tropicalis)
        
        pik3r6 [cytosol] (Xenopus tropicalis)
    - PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
      - Activator:PI3K [plasma membrane] (Xenopus tropicalis)
        
        CD28:PI3K [plasma membrane] (Xenopus tropicalis)
        
        Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        PI3K gamma [cytosol] (Xenopus tropicalis)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Xenopus tropicalis)
        
        pik3r6 [cytosol] (Xenopus tropicalis)
        
        ICOS:PI3K [plasma membrane] (Xenopus tropicalis)
        
        Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        PI3K gamma [cytosol] (Xenopus tropicalis)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Xenopus tropicalis)
        
        pik3r6 [cytosol] (Xenopus tropicalis)
- Signaling by GPCR (Xenopus tropicalis)
  - GPCR downstream signalling (Xenopus tropicalis)
    - G-protein beta:gamma signalling (Xenopus tropicalis)
      - G beta:gamma signalling through PI3Kgamma (Xenopus tropicalis)
        
        G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Xenopus tropicalis)
        
        G-protein beta-gamma:PI3K gamma [plasma membrane] (Xenopus tropicalis)
        
        PI3K gamma [cytosol] (Xenopus tropicalis)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Xenopus tropicalis)
        
        pik3r6 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F6RLH3

Gene Names

pik3r6

Reference Genes

BioGPS Gene:780316 pik3r6

ENSEMBL:ENSXETG00000019512

Monarch:780316 pik3r6

NCBI Gene:780316 pik3r6

UCSC:F6RLH3 pik3r6

Reference Transcript

Other Identifiers

780316

GO:0005942

GO:0005944

GO:0007186

GO:0042269

GO:0046935

Participates

as a component of

PIK3CG:PIK3R6 [cytosol] (Xenopus tropicalis)

as a member of

PI3-kinase gamma, regulatory subunit [cytosol] (Xenopus tropicalis)

Inferred From

PIK3R6 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_012809713.2, XP_031750041.1, XP_017945557.2, XP_012809712.2, XP_012809716.2, XP_012809711.2, XP_031750040.1, XP_012809715.2, XP_012809714.2

ENSEMBL

ENSXETP00000071908, ENSXETP00000042238, ENSXETP00000072280, ENSXETG00000019512, ENSXETT00000075568, ENSXETT00000042238, ENSXETT00000094383

Xenbase

XB-GENE-989316

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