Reactome | xx [extracellular region]

xx [extracellular region]

Stable Identifier

R-XTR-2268628

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL5A3, A0A803J8Y6

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Xenopus tropicalis)

- Collagen formation (Xenopus tropicalis)
  - Assembly of collagen fibrils and other multimeric structures (Xenopus tropicalis)
    - Formation of collagen fibres (Xenopus tropicalis)
      - Collagen fibres [extracellular region] (Xenopus tropicalis)
        
        Collagen type V fibre [extracellular region] (Xenopus tropicalis)
        
        Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
      - Collagen fibrils [extracellular region] (Xenopus tropicalis)
        
        Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
    - Formation of collagen fibrils (Xenopus tropicalis)
      - Collagen fibrils [extracellular region] (Xenopus tropicalis)
        
        Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
      - Tropocollagens [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
  - Collagen biosynthesis and modifying enzymes (Xenopus tropicalis)
    - Removal of fibrillar collagen N-propeptides (Xenopus tropicalis)
      - Fibrillar procollagens [extracellular region] (Xenopus tropicalis)
        
        Procollagen type V [extracellular region] (Xenopus tropicalis)
        
        Procollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
- Degradation of the extracellular matrix (Xenopus tropicalis)
  - Collagen degradation (Xenopus tropicalis)
    - Collagen type V degradation by MMP2,9,10 (Xenopus tropicalis)
      - Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
- ECM proteoglycans (Xenopus tropicalis)
  - VTN binds collagens II, III and V (Xenopus tropicalis)
    - Collagen types II, III, V [extracellular region] (Xenopus tropicalis)
      - Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
    - VTN:Collagen types II,III,V [extracellular region] (Xenopus tropicalis)
      - Collagen types II, III, V [extracellular region] (Xenopus tropicalis)
        
        Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
- Fibronectin matrix formation (Xenopus tropicalis)
  - FN1 binds Collagen types I-V, VII (Xenopus tropicalis)
    - Collagen types I-V, VII [extracellular region] (Xenopus tropicalis)
      - Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
    - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Xenopus tropicalis)
      - Collagen types I-V, VII [extracellular region] (Xenopus tropicalis)
        
        Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
- Integrin cell surface interactions (Xenopus tropicalis)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Xenopus tropicalis)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Xenopus tropicalis)
      - Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Xenopus tropicalis)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Xenopus tropicalis)
        
        Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
- Non-integrin membrane-ECM interactions (Xenopus tropicalis)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Xenopus tropicalis)
    - Collagen types I-V, VII [extracellular region] (Xenopus tropicalis)
      - Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Xenopus tropicalis)
      - Collagen types I-V, VII [extracellular region] (Xenopus tropicalis)
        
        Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by PDGF (Xenopus tropicalis)
    - PDGF binds to extracellular matrix proteins (Xenopus tropicalis)
      - Extracellular matrix ligands [extracellular region] (Xenopus tropicalis)
        
        Collagens [extracellular region] (Xenopus tropicalis)
        
        Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
      - PDGF A and B chains:ECM complex [extracellular region] (Xenopus tropicalis)
        
        Extracellular matrix ligands [extracellular region] (Xenopus tropicalis)
        
        Collagens [extracellular region] (Xenopus tropicalis)
        
        Collagen V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type V [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-3(V) [extracellular region] (Xenopus tropicalis)
        
        xx [extracellular region] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A803J8Y6

Gene Names

Reference Genes

BioGPS Gene:100497990 xx

ENSEMBL:ENSXETG00000011757

Monarch:100497990 xx

NCBI Gene:100497990 xx

UCSC:A0A803J8Y6 xx

Reference Transcript

RefSeq:XM_012953005.3 xx

Other Identifiers

100497990

GO:0005198

GO:0005201

GO:0005576

GO:0005581

GO:0030020

GO:0030312

GO:0031012

Participates

as a component of

Other forms of this molecule

xx [endoplasmic reticulum lumen]

xx [extracellular region]

xx [endoplasmic reticulum lumen]

Inferred From

Alpha-3(V) propeptides [extracellular region] (Homo sapiens)

Collagen alpha-3(V) chains [extracellular region] (Homo sapiens)

3x4Hyp-3Hyp-GalHyl-COL5A3 [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

RefSeq

XP_012808459.1

ENSEMBL

ENSXETT00000110591, ENSXETP00000104288, ENSXETG00000011757

Cite Us!