Reactome | col7a1 [extracellular region]

col7a1 [extracellular region]

Stable Identifier

R-XTR-2127335

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL4A5, A0A803JG94

Locations in the PathwayBrowser

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Extracellular matrix organization (Xenopus tropicalis)

- Collagen formation (Xenopus tropicalis)
  - Assembly of collagen fibrils and other multimeric structures (Xenopus tropicalis)
    - Formation of collagen networks (Xenopus tropicalis)
      - Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col7a1 [extracellular region] (Xenopus tropicalis)
- Degradation of the extracellular matrix (Xenopus tropicalis)
  - Collagen degradation (Xenopus tropicalis)
    - Collagen type IV degradation by MMP2,3,4,9,10,12 (Xenopus tropicalis)
      - Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col7a1 [extracellular region] (Xenopus tropicalis)
- Fibronectin matrix formation (Xenopus tropicalis)
  - FN1 binds Collagen types I-V, VII (Xenopus tropicalis)
    - Collagen types I-V, VII [extracellular region] (Xenopus tropicalis)
      - Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col7a1 [extracellular region] (Xenopus tropicalis)
    - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Xenopus tropicalis)
      - Collagen types I-V, VII [extracellular region] (Xenopus tropicalis)
        
        Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col7a1 [extracellular region] (Xenopus tropicalis)
- Integrin cell surface interactions (Xenopus tropicalis)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Xenopus tropicalis)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Xenopus tropicalis)
      - Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col7a1 [extracellular region] (Xenopus tropicalis)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Xenopus tropicalis)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Xenopus tropicalis)
        
        Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col7a1 [extracellular region] (Xenopus tropicalis)
- Non-integrin membrane-ECM interactions (Xenopus tropicalis)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Xenopus tropicalis)
    - Collagen types I-V, VII [extracellular region] (Xenopus tropicalis)
      - Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col7a1 [extracellular region] (Xenopus tropicalis)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Xenopus tropicalis)
      - Collagen types I-V, VII [extracellular region] (Xenopus tropicalis)
        
        Collagen IV [extracellular region] (Xenopus tropicalis)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen alpha-1(IV).alpha-2(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Xenopus tropicalis)
        
        col7a1 [extracellular region] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A803JG94

Gene Names

col7a1

Reference Genes

BioGPS Gene:100489404 col7a1

ENSEMBL:ENSXETG00000008729

KEGG:xtr:100489404 col7a1

Monarch:100489404 col7a1

NCBI Gene:100489404 col7a1

UCSC:A0A803JG94 col7a1

Reference Transcript

RefSeq:XM_012961678.2 col7a1

Other Identifiers

100489404

GO:0004867

GO:0005198

GO:0005576

GO:0005581

GO:0005587

GO:0030020

GO:0030312

GO:0031012

GO:0098772

Participates

as a component of

Other forms of this molecule

col7a1 [endoplasmic reticulum lumen]

col7a1 [extracellular region]

Inferred From

Collagen alpha-5(IV) chains [extracellular region] (Homo sapiens)

3x4Hyp-3Hyp-GalHyl-COL4A5 [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

RefSeq

XP_012817132.2

ENSEMBL

ENSXETP00000106961, ENSXETG00000016183, ENSXETT00000110754

Xenbase

XB-GENE-22068291