Reactome | phospho-dvl2 [cytosol]

phospho-dvl2 [cytosol]

Stable Identifier

R-XTR-201706

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

p-DVL2, Q05AS8

Locations in the PathwayBrowser

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Vesicle-mediated transport (Xenopus tropicalis)

- Membrane Trafficking (Xenopus tropicalis)
  - Clathrin-mediated endocytosis (Xenopus tropicalis)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Xenopus tropicalis)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        phospho-dvl2 [cytosol] (Xenopus tropicalis)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        phospho-dvl2 [cytosol] (Xenopus tropicalis)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Xenopus tropicalis)
      - CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Xenopus tropicalis)
        
        phospho-dvl2 [cytosol] (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Xenopus tropicalis)
        
        phospho-dvl2 [cytosol] (Xenopus tropicalis)
    - Cargo recognition for clathrin-mediated endocytosis (Xenopus tropicalis)
      - ARBB recruits GPCRs into clathrin-coated pits (Xenopus tropicalis)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Xenopus tropicalis)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Xenopus tropicalis)
        
        phospho-dvl2 [cytosol] (Xenopus tropicalis)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Xenopus tropicalis)
        
        phospho-dvl2 [cytosol] (Xenopus tropicalis)
      - ARRB bind GPCRs (Xenopus tropicalis)
        
        ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Xenopus tropicalis)
        
        phospho-dvl2 [cytosol] (Xenopus tropicalis)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Xenopus tropicalis)
        
        phospho-dvl2 [cytosol] (Xenopus tropicalis)
    - Clathrin recruits PIK3C2A (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Xenopus tropicalis)
        
        phospho-dvl2 [cytosol] (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Xenopus tropicalis)
        
        phospho-dvl2 [cytosol] (Xenopus tropicalis)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        ARRB-binding GPCRs [plasma membrane] (Xenopus tropicalis)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Xenopus tropicalis)
        
        phospho-dvl2 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q05AS8

Gene Names

dvl2

Reference Genes

BioGPS Gene:780117 dvl2

ENSEMBL:ENSXETG00000046940

KEGG:xtr:780117 dvl2

Monarch:780117 dvl2

NCBI Gene:780117 dvl2

UCSC:Q05AS8 dvl2

Reference Transcript

RefSeq:NM_001079192.1 dvl2

Other Identifiers

780117

GO:0001702

GO:0001736

GO:0001843

GO:0005109

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0005929

GO:0007163

GO:0007369

GO:0009948

GO:0009950

GO:0009986

GO:0016020

GO:0016055

GO:0022008

GO:0030030

GO:0030154

GO:0031410

GO:0032053

GO:0035253

GO:0035556

GO:0042802

GO:0042995

GO:0043226

GO:0044782

GO:0045545

GO:0046875

GO:0048013

GO:0050821

GO:0060026

GO:0060027

GO:0060070

GO:0060271

GO:0090630

Participates

as a component of

as an input of

WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Xenopus tropicalis)

Other forms of this molecule

dvl2 [cytosol]

phospho-dvl2 [clathrin-coated endocytic vesicle]

dvl2 [cytosol]

phospho-dvl2 [cytosol]

Inferred From

p-DVL [cytosol] (Homo sapiens)

p-DVL2 [cytosol] (Homo sapiens)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_001072660.1

ENSEMBL

ENSXETP00000107992, ENSXETG00000046940, ENSXETT00000110531

Xenbase

XB-GENE-1017461

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