Reactome | eps15 [cytosol]

eps15 [cytosol]

Stable Identifier

R-XTR-182920

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

EPS15, A0A8J0Q9H0

Locations in the PathwayBrowser

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Cell-Cell communication (Xenopus tropicalis)

- Cell junction organization (Xenopus tropicalis)
  - Cell-cell junction organization (Xenopus tropicalis)
    - Adherens junctions interactions (Xenopus tropicalis)
      - Regulation of Homotypic Cell-Cell Adhesion (Xenopus tropicalis)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Xenopus tropicalis)
        
        Regulation of CDH1 Expression and Function (Xenopus tropicalis)
        
        Regulation of CDH1 Function (Xenopus tropicalis)
        
        Degradation of CDH1 (Xenopus tropicalis)
        
        The complex of MDM2 and CDH1 translocates to early endosomes (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)

Vesicle-mediated transport (Xenopus tropicalis)

- Membrane Trafficking (Xenopus tropicalis)
  - Clathrin-mediated endocytosis (Xenopus tropicalis)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Xenopus tropicalis)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Xenopus tropicalis)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Xenopus tropicalis)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Xenopus tropicalis)
      - CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
    - Cargo recognition for clathrin-mediated endocytosis (Xenopus tropicalis)
      - ARBB recruits GPCRs into clathrin-coated pits (Xenopus tropicalis)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
        
        UNQLNs:UIM proteins [cytosol] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
      - Epsin family proteins bind ubiquitinated cargo (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
      - UBQLNs bind UIM-containing adaptor proteins (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
        
        UNQLNs:UIM proteins [cytosol] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
    - Clathrin recruits PIK3C2A (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2 [cytosol] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Xenopus tropicalis)
        
        eps15 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A8J0Q9H0

Gene Names

eps15

Reference Genes

BioGPS Gene:100145116 eps15

ENSEMBL:ENSXETG00000002833

KEGG:xtr:100145116 eps15

Monarch:100145116 eps15

NCBI Gene:100145116 eps15

UCSC:A0A8J0Q9H0 eps15

Reference Transcript

RefSeq:NM_001126628.2 eps15

Participates

as a component of

as a member of

EPS15,EPN1,EPN2 [cytosol] (Xenopus tropicalis)

This entity regulates

Positively

The complex of MDM2 and CDH1 translocates to early endosomes (Xenopus tropicalis)

Other forms of this molecule

phospho-eps15 [cytosol]

Inferred From

EPS15 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001120100.2

Xenbase

XB-GENE-6070905

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